Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi

Revista da Sociedade Brasileira de Medicina Tropical

F. Santoro²  M. Sadigursky¹  I. Sherlock¹  D. Afchain²  A. Capron² 

[1] ,Institut Pasteur Centre d’immunologie et de Biologie Parasitaire ,France

关键词: Trypanosoma cruzi;    Antibodies;    Immunoassay;    Trypanosoma cruzi;    Anticorpos;    Imuno-ensaio;   

DOI  :  10.1590/S0037-86821987000200005

来源: SciELO

【 摘 要 】

A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease.

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