Tuberculosis among HIV-1-infected subjects in a tertiary out-patient service in São Paulo city, Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Jorge Casseb¹  Luiz Augusto M. Fonseca¹  Lucas A. Medeiros¹  Claudio R. Gonsalez¹  Eduardo R. Lagonegro¹  Ana Paula Rocha Veiga¹  Daniela C. Da Silva¹  Marcelo Mendonça¹  Alberto J. S. Duarte¹ 

[1] ,São Paulo University Medical School São Paulo SP ,Brazil

关键词: AIDS;    Brazil;    Co-infection;    Incidence;    HIV;    Mortality;    TB;   

DOI  :  10.1590/S0036-46652012000500004

来源: SciELO

【 摘 要 】

TB is currently considered to be the most important infectious disease among HIV-1-infected subjects in developing countries, such as Brazil. A retrospective analysis of TB cases was performed, occurring from January 1995 to December 2010 in our cohort of 599 HIV positive patients. The primary outcome was the occurrence of active TB. Forty-one TB cases were diagnosed over this period of 16 years, among 599 HIV positive patients in an open cohort setting in the city of Sao Paulo, Brazil. All-time lowest mean CD4 T cell count at the time of TB diagnosis was 146 and 186 cells/mm³, respectively. The mean HIV viral load was 5.19 log10 copies/mL, and 59% of the patients were on HAART. TB incidence was 1.47 per 100 person-years, for a total follow-up time of 2775 person-years. The probability of surviving up to 10 years after diagnosis was 75% for TB patients as opposed to 96% for patients with other, non-TB opportunistic diseases (p = 0.03). TB can be considered a public health problem among people living with HIV in Brazil despite of the widespread use of antiretrovirals for the treatment of HIV infection/AIDS.

【 授权许可】

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