Complete cure of HBV-HDV co-infection after 24 weeks of combination therapy with pegylated interferon and ribavirin in a patient co-infected with HBV/HCV/HDV/HIV

JOURNAL OF HEPATOLOGY

卷:50

Article

Gozlan, Joel^1,4  Lacombe, Karine^2,5  Gault, Elyanne³  Raguin, Gilles²  Girard, Pierre-Marie^2,5 

[1] Hop St Antoine, Serv Bacteriol Virol, F-75012 Paris, France

[2] Hop St Antoine, Serv Malad Infect, F-75012 Paris, France

[3] Hop Avicenne, Serv Bacteriol Virol, F-93009 Bobigny, France

[4] Univ Paris 06, INSERM, UMR S 872, Ctr Rech Cordeliers, Paris, France

[5] Univ Paris 06, INSERM, UMR S707, Paris, France

关键词: Hepatitis B;    Hepatitis delta;    Hepatitis C;    AIDS;    Pegylated-interferon;    Co-infection;   

DOI  :  10.1016/j.jhep.2008.05.029

来源: Elsevier

【 摘 要 】

Multiple hepatitis co-infections are frequent in HIV-infected patients, often resulting in severe liver diseases that are difficult to treat. We report here the complete resolution of a chronic hepatitis B and D co-infection in a patient who was also infected with HCV and HIV. This cure was observed after 24 weeks of combination therapy associating pegylated-IFN and ribavirin, which was initially given to treat HCV. An unexpected and extensive HDV replication was observed in this patient after HBs Ag had cleared from the serum, which was followed by a stable halt in HDV replication. Implications of this unusual observation will be discussed. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

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