Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalite 2005 study

JOURNAL OF HEPATOLOGY

卷:50

Article

Salmon-Ceron, Dominique^1,2  Rosenthal, Eric^3,4  Lewden, Charlotte^5,6  Bouteloup, Vincent⁵  May, Thierry^7,8  Burty, Christine⁷  Bonnet, Fabrice^6,9  Costagliola, Dominique^10,11  Jougla, Eric¹²  Semaille, Caroline¹³  Morlat, Philippe^5,6,9  Cacoub, Patrice^11,14  Chene, Genevieve^5,6,9 

[1] Univ Paris 05, Dept Internal Med, Hop Cochin, F-75014 Paris, France

[2] Ctr Hosp Univ Cochin, AP HP, Paris, France

[3] Univ Sofia Antipolis, Nice, France

[4] Ctr Hosp Univ Archet, Nice, France

[5] INSERM, U897, Bordeaux, France

[6] Univ Bordeaux 2, ISPED, F-33076 Bordeaux, France

[7] Ctr Hosp Univ Brabois, Vandoeuvre Les Nancy, France

[8] Univ Henri Poincare, Nancy, France

[9] Ctr Hosp Univ, Bordeaux, France

[10] INSERM, UMR720, Paris, France

[11] Univ Paris 06, Paris, France

[12] INSERM, CepiDc, Le Vesinet, France

[13] Inst Veille Sanit, St Maurice, France

[14] CHU Pitie Salpetriere, Paris, France

关键词: End-stage liver disease;    Deaths;    Hepatocellular carcinoma;    HIV infection;    Hepatitis B;    Hepatitis C;    AIDS;    Mortality;    HAART;   

DOI  :  10.1016/j.jhep.2008.11.018

来源: Elsevier

【 摘 要 】

Background/Aims: Longer exposure to hepatitis C (HCV) or B virus (HBV) and the increased use of hepatitis treatment might have an impact on liver-related deaths in patients co-infected with the Human Immunodeficiency Virus (HIV). We describe the proportion of liver-related deaths among HIN-infected patients in 2005 compared with 2000. Methods: In a nationwide survey (341 hospital departments involved in HIV management), all deaths of HIV-infected patients were prospectively reported. Deaths from either cirrhosis, hepatocellular carcinoma or fulminant hepatitis were defined as liver-related deaths. Results: Of the 898 deaths reported in 2005, liver-related causes accounted for 15.4%; this is compared to 13.4% in 2000. Among liver-related deaths, hepatocellular carcinoma increased from 15% to 25% (p = 0.04). Among hepatocellular carcinoma-related deaths: in 2000, 10%, were HCV-infected; in 2005, 25% were HCV-infected (p = 0.03). Half of the HCV-related deaths had been treated for HCV but 98% remained HCV-RNA positive at time of death. The proportion of HBV-related deaths remained stable between 2000 and 2005. Conclusions: Liver-related deaths, mainly liver cancers, have increased in HIV-infected patients in France despite wide access to HCV treatment. The stability of HBV-related deaths might be explained by the use of dually active antiretroviral drugs in co-infected patients. (c) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

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