期刊论文详细信息
Revista do Instituto de Medicina Tropical de São Paulo
Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects
Daniel Vítor V. Santos2  Maria Margarida R. Souza2  Sérgio Henrique L. GonÇalves2  Ana Cristina S. Cotta2  Lorenza A. O. Melo1  Gláucia M. Q. Andrade1  Geraldo Brasileiro-filho2 
[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Anatomia Patológica e Medicina LegalBelo Horizonte MG ,Brasil
关键词: Cytomegalovirus;    Congenital infection;    Neonatal Intensive Care Unit (NICU);    PCR;   
DOI  :  10.1590/S0036-46652000000300003
来源: SciELO
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【 摘 要 】

Cytomegalovirus (CMV) infection is the most common congenital infection, affecting 0.4% to 2.3% newborns. Most of them are asymptomatic at birth, but later 10% develop handicaps, mainly neurological disturbances. Our aim was to determine the prevalence of CMV shed in urine of newborns from a neonatal intensive care unit using the polymerase chain reaction (PCR) and correlate positive cases to some perinatal aspects. Urine samples obtained at first week of life were processed according to a PCR protocol. Perinatal data were collected retrospectively from medical records. Twenty of the 292 cases (6.8%) were CMV-DNA positive. There was no statistical difference between newborns with and without CMV congenital infection concerning birth weight (p=0.11), gestational age (p=0.11), Apgar scores in the first and fifth minutes of life (p=0.99 and 0.16), mother's age (p=0.67) and gestational history. Moreover, CMV congenital infection was neither related to gender (p=0.55) nor to low weight (<2,500g) at birth (p=0.13). This high prevalence of CMV congenital infection (6.8%) could be due to the high sensitivity of PCR technique, the low socioeconomic level of studied population or the severe clinical status of these newborns.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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