Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects

Revista do Instituto de Medicina Tropical de São Paulo

Daniel Vítor V. Santos²  Maria Margarida R. Souza²  Sérgio Henrique L. GonÇalves²  Ana Cristina S. Cotta²  Lorenza A. O. Melo¹  Gláucia M. Q. Andrade¹  Geraldo Brasileiro-filho² 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Anatomia Patológica e Medicina LegalBelo Horizonte MG ,Brasil

关键词: Cytomegalovirus;    Congenital infection;    Neonatal Intensive Care Unit (NICU);    PCR;   

DOI  :  10.1590/S0036-46652000000300003

来源: SciELO

【 摘 要 】

Cytomegalovirus (CMV) infection is the most common congenital infection, affecting 0.4% to 2.3% newborns. Most of them are asymptomatic at birth, but later 10% develop handicaps, mainly neurological disturbances. Our aim was to determine the prevalence of CMV shed in urine of newborns from a neonatal intensive care unit using the polymerase chain reaction (PCR) and correlate positive cases to some perinatal aspects. Urine samples obtained at first week of life were processed according to a PCR protocol. Perinatal data were collected retrospectively from medical records. Twenty of the 292 cases (6.8%) were CMV-DNA positive. There was no statistical difference between newborns with and without CMV congenital infection concerning birth weight (p=0.11), gestational age (p=0.11), Apgar scores in the first and fifth minutes of life (p=0.99 and 0.16), mother's age (p=0.67) and gestational history. Moreover, CMV congenital infection was neither related to gender (p=0.55) nor to low weight (<2,500g) at birth (p=0.13). This high prevalence of CMV congenital infection (6.8%) could be due to the high sensitivity of PCR technique, the low socioeconomic level of studied population or the severe clinical status of these newborns.

【 授权许可】

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