Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

Revista Ceres

Alexandre Couto Tsiomis¹  Andréa Pacheco Batista Borges¹  Ana Paula Falci Daibert¹  Tatiana Schmitz Duarte¹  Emily Correna Carlo Reis¹  Tatiana Borges Carvalho¹ 

关键词: Biomaterials;    bone substitute;    bone regeneration;    Biomaterial;    substituto ósseo;    regeneração óssea;   

DOI  :  10.1590/S0034-737X2011000200003

来源: SciELO

【 摘 要 】

Bone loss, either by trauma or other diseases, generates an increasing need for substitutes of this tissue. This study evaluated Bioglass as a bone substitute in the regeneration of the alveolar bone in mandibles of dogs by clinical, surgical and radiological analysis. Twenty-eight adult dogs were randomly separated into two equal groups. In each animal, a bone defect was created on the vestibular surface of the alveolar bone between the roots of the fourth right premolar tooth. In the treated group, the defect was immediately filled with bioglass, while in the control, it remained unfilled. Clinical evaluations were performed daily for a week, as well as x-rays immediately after surgery and at 8, 14, 21, 42, 60, 90 and 120 days post-operative. Most animals in both groups showed no signs of inflammation and wound healing was similar. Radiographic examination revealed a gradual increase of radiopacity in the region of the defect in the control group. In the treated group, initial radiopacity was higher than that of adjacent bone, decreasing until 21 days after surgery. Then it gradually increased until 120 days after surgery, when the defect became undetectable. The results showed that Bioglass integrates into bone tissue, is biocompatible and reduced the period for complete bone regeneration.

【 授权许可】

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