Arquivos de Neuro-Psiquiatria | |
Alzheimer's disease qEEG: spectral analysis versus coherence. which is the best measurement? | |
Renato Anghinah2 Paulo Afonso Medeiros Kanda2 Helder Frederico Lopes2 Luis Fernando Hindi Basile2 Sérgio Machado1 Pedro Ribeiro1 Bruna Velasques1 Koichi Sameshima1 Daniel Yasumasa Takahashi1 Lécio Figueira Pinto2 Paulo Caramelli1 Ricardo Nitrini2 | |
[1] ,University of São Paulo School of Medicine Departments of NeurologySão Paulo SP ,Brazil | |
关键词: electroencephalography; Alzheimer's disease; dementia; EEG; spectral analysis; coherence; eletroencefalografia; doença de Alzheimer; demência; EEG; análise espectral; coerência; | |
DOI : 10.1590/S0004-282X2011000700004 | |
来源: SciELO | |
【 摘 要 】
There is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for Alzheimer's disease (AD). We compared the sensitivity and specificity between spectral analysis (spectA) and coherence (Coh) within the same group of AD patients. SpectA and Coh were calculated from EEGs of 40 patients with mild to moderate AD and 40 healthy elderly controls. The peak of spectA was smaller in the AD group than in controls. AD group showed predominance of slow spectA in theta and delta bands and a significant reduction of inter-hemispheric Coh for occipital alpha 2 and beta 1 and for frontal delta sub-band. ROC curve supported that alpha band spectA was more sensitive than coherence to differentiate controls from AD.
【 授权许可】
CC BY
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