Alzheimer's disease qEEG: spectral analysis versus coherence. which is the best measurement?

Arquivos de Neuro-Psiquiatria

Renato Anghinah²  Paulo Afonso Medeiros Kanda²  Helder Frederico Lopes²  Luis Fernando Hindi Basile²  Sérgio Machado¹  Pedro Ribeiro¹  Bruna Velasques¹  Koichi Sameshima¹  Daniel Yasumasa Takahashi¹  Lécio Figueira Pinto²  Paulo Caramelli¹  Ricardo Nitrini² 

[1] ,University of São Paulo School of Medicine Departments of NeurologySão Paulo SP ,Brazil

关键词: electroencephalography;    Alzheimer's disease;    dementia;    EEG;    spectral analysis;    coherence;    eletroencefalografia;    doença de Alzheimer;    demência;    EEG;    análise espectral;    coerência;   

DOI  :  10.1590/S0004-282X2011000700004

来源: SciELO

【 摘 要 】

There is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for Alzheimer's disease (AD). We compared the sensitivity and specificity between spectral analysis (spectA) and coherence (Coh) within the same group of AD patients. SpectA and Coh were calculated from EEGs of 40 patients with mild to moderate AD and 40 healthy elderly controls. The peak of spectA was smaller in the AD group than in controls. AD group showed predominance of slow spectA in theta and delta bands and a significant reduction of inter-hemispheric Coh for occipital alpha 2 and beta 1 and for frontal delta sub-band. ROC curve supported that alpha band spectA was more sensitive than coherence to differentiate controls from AD.

【 授权许可】

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