Association between the SLC6A3 A1343G polymorphism and schizophrenia

Arquivos de Neuro-Psiquiatria

Quirino Cordeiro¹  Jacqueline Siqueira-roberto¹  Homero Vallada¹ 

[1] ,University of São Paulo Medical School Department of PsychiatrySão Paulo SP ,Brazil

关键词: association study;    dopamine;    dopamine transporter;    genetics;    psychosis;    estudo de associação;    dopamina;    transportador de dopamina;    genética;    psicose;   

DOI  :  10.1590/S0004-282X2010000500008

来源: SciELO

【 摘 要 】

Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between a new single nucleotide polymorphism (rs6347) located in exon 9 of the protein transporter (SLC6A3) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 235 patients and 834 controls matched by gender and age. There were statistical differences in the allelic (χ2=5.97, 1d.f. , p=0.01, OR=1.33-1.05

【 授权许可】

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