期刊论文详细信息
Arquivos de Neuro-Psiquiatria
Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
Quirino Cordeiro1  Homero Vallada1 
关键词: association study;    dopamine;    genetics;    psychosis;    estudo de associação;    dopamina;    genética;    psicose;   
DOI  :  10.1590/0004-282X20140100
来源: SciELO
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【 摘 要 】

Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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