Alcohol consumption and sudden unexpected death in epilepsy: experimental approach

Arquivos de Neuro-Psiquiatria

Carla A. Scorzai²  Roberta M. Cysneiros¹  Ricardo M. Arida¹  Vera C. Terra¹  Hélio R. Machado¹  Antonio-carlos G. De Almeida¹  Esper A. Cavalheiro²  Fulvio A. Scorza² 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina São Paulo SP ,Brazil

关键词: epilepsy;    alcohol;    heart;    seizure;    SUDEP;    epilepsia;    álcool;    coração;    crise epiléptica;    SUDEP;   

DOI  :  10.1590/S0004-282X2009000600008

来源: SciELO

【 摘 要 】

Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.

【 授权许可】

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