Carbamazepine does not alter the intrinsic cardiac function in rats with epilepsy

Arquivos de Neuro-Psiquiatria

Diego B Colugnati²  Ricardo M Arida¹  Roberta M Cysneiros¹  Vera C Terra¹  Eliza Y.f Sonoda²  Aline P Pansani²  Carla A Scorza²  Esper A Cavalheiro²  Fulvio A Scorza² 

[1] ,Federal University of São Paulo Paulist Medicine School São Paulo SP ,Brazil

关键词: epilepsy;    heart;    SUDEP;    seizure;    antiepileptic drugs;    carbamazepine;    epilepsia;    coração;    SUPED;    convulsão;    drogas antiepilépticas;    carbamazepina;   

DOI  :  10.1590/S0004-282X2010000400018

来源: SciELO

【 摘 要 】

Among the causes for sudden unexpected death (SUDEP) in epilepsy, the effects of antiepileptic drugs on the heart have been poorly explored. Based on this, the aim of our study was to evaluate the heart rate (in vivo and isolated ex vivo) and ventricular pressure (isolated ex vivo) of rats with and without epilepsy treated with carbamazepine. Four groups of adult, male Wistar rats (200-250 g) were studied: [A] control rats (n=8), received neither pilocarpine nor carbamazepine [B] carbamazepine-treated rats (n=8), received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks; [C] rats with epilepsy that received just saline solution (n=8); [D] rats with epilepsy that received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks (n=8). Our results showed significant increase in heart rate in animals with epilepsy (with and without the use of carbamazepine) when compared to the control groups in vivo. In contrast, we did not find differences during isolated ex vivo experiments comparing animals with and without epilepsy and despite the use of carbamazepine. Our results suggest that, in isolation, carbamazepine may not be a potential risk factor for sudden unexpected death in epilepsy.

【 授权许可】

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