Is cold the new hot in sudden unexpected death in epilepsy? Effect of low temperature on heart rate of rats with epilepsy

Arquivos de Neuro-Psiquiatria

Eliza Y.f. Sonoda¹  Diego B. Colugnati¹  Carla A. Scorza¹  Ricardo M. Arida²  Aline P. Pansani¹  Antonio-carlos G. De Almeida²  Esper A. Cavalheiro¹  Fulvio A. Scorza¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina São Paulo SP ,Brasil

关键词: epilepsy;    seizure;    SUDEP;    low temperatures;    heart;    epilepsia;    crises epilépticas;    SUDEP;    baixas temperaturas;    coração;   

DOI  :  10.1590/S0004-282X2008000600014

来源: SciELO

【 摘 要 】

Sudden unexpected death in epilepsy (SUDEP) is the commonest cause of seizure-related mortality in people with refractory epilepsy. Several risk factors for SUDEP are described; however, the importance of including low temperatures as risk factor for SUDEP was never explored. Based on this, the aim of this study was to evaluate the heart rate of rats with epilepsy during low temperature exposure. Our results showed that low temperature clearly increased the heart rate of rats with epilepsy. Taken together, we concluded that exposure to low temperatures could be considered important risk factors from cardiovascular abnormalities and hence sudden cardiac death in epilepsy.

【 授权许可】

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