期刊论文详细信息
Arquivos de Neuro-Psiquiatria
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample
Karen Miguita2  Quirino Cordeiro2  Jacqueline Siqueira-roberto2  Roseli Gedanke Shavitt1  José Carlos Ramos Castillo2  Ana Regina Castillo2  Euripedes Constantino Miguel1  Homero Vallada1 
[1] ,USP FM HCSão Paulo SP ,Brazil
关键词: dopamine;    obsessive-compulsive disorder;    genetic association;    DAT1;    allele;    genotype;    dopamina;    associação genética;    DAT1;    alelo;    genótipo;   
DOI  :  10.1590/S0004-282X2007000600002
来源: SciELO
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【 摘 要 】

Family, twin and segregation analysis have provided evidences that genetic factors are implicated in the susceptibility for obsessive-compulsive disorder (OCD). Several lines of research suggest that the dopaminergic system may be involved in the pathophysiology of OCD. Thus, the aim of the present study was to investigate a possible association between a polymorphism located in intron 8 of the dopamine transporter gene (SLC6A3) and OCD in a Brazilian sample composed by 208 patients and 865 healthy controls. No statistically differences were observed in allelic and genotype distributions between cases and controls. No association was also observed when the sample was divided according to specific phenotypic features such as gender, presence of tic disorders co-morbidity and age at onset of obsessive-compulsive symptoms (OCS). Our results suggest that the intron 8 VNTR of the SLC6A3 investigated in this study is not related to the susceptibility for OCD in our Brazilian sample.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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