Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample

Arquivos de Neuro-Psiquiatria

Quirino Cordeiro²  Michael Talkowski¹  Joel Wood¹  Eliza Ikenaga²  Homero Vallada² 

[1] ,University of Sao Paulo School of Medicine Department of PsychiatrySão Paulo SP ,Brazil

关键词: DAT1;    SLC6A3;    schizophrenia;    genetic polymorphism;    genetic association;    trios;    DAT1;    SLC6A3;    esquizofrenia;    polimorfismo genético;    associação genética;    trios;   

DOI  :  10.1590/S0004-282X2004000600008

来源: SciELO

【 摘 要 】

A role of dopaminergic dysfunction has been postulated in the aetiology of schizophrenia. We hypothesized that variations in the dopamine transporter gene (SLC6A3) may be associated with schizophrenia. We conducted case-control and family based analysis on the polymorphic SLC6A3 variable number tandem repeat (VNTR) in a sample of 220 schizophrenic patients, 226 gender and ethnic matched controls, and 49 additional case-parent trios. No differences were found in allelic or genotypic distributions between cases and controls and no significant transmission distortions from heterozygous parents to schizophrenic offspring were detected. Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License