C3c intrathecal synthesis evaluation in patients with multiple sclerosis

Arquivos de Neuro-Psiquiatria

Bárbara Padilla-docal¹  Alberto J Dorta-contreras¹  Hermes Fundora-hernández¹  Elena Noris-garcía¹  Raisa Bu-coifiu-fanego¹  Marlen González-hernández¹  Alexis Rodríguez-rey¹ 

[1] ,Laboratorio Central de Líquido Cefalorraquídeo

关键词: cytotoxicity;    complement;    multiple sclerosis;    hypersensibility;    immunopathogenicity;    reibergram;    citotoxicidad;    complemento;    esclerosis múltiple;    hipersensibilidad;    inmunopatogenia;    reibergrama;   

DOI  :  10.1590/S0004-282X2007000500013

来源: SciELO

【 摘 要 】

INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss (demyelination). OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. METHOD: Samples of sera and CSF from twelve patients with a diagnosis of MS obtained at the moment of the admission to the hospital at the beginning of the break out, were collected. Levels of C3c and albumin in sera and in CSF were quantified using radial immunodiffusion plates. RESULTS: High values over 80% of intrathecal synthesis were obtained except in one of the patients. CONCLUSION: Intrathecal synthesis of C3c and its liberation to the CSF means that the activation of the complement system in any of the two ways has taken place, and that once performed its biological functions, has suffered a degradation process.

【 授权许可】

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