Complement component anaphylatoxins upregulate chemokine expression by human astrocytes

FEBS Letters

Chan, Philippe²  Fontaine, Marc²  Jauneau, Anne-Christine²  Ischenko, Alexander¹ 

[1] Research Institute of Highly Pure Biopreparations, St Petersburg, Russia;Institut Fédératif de Recherche Multidisciplinaire sur les Peptides No. 23, INSERM U519, Faculté Mixte de Médecine et de Pharmacie, 22 Boulevard Gambetta, 76183 Rouen Cedex, France

关键词: Complement;    Brain;    Astrocyte;    Anaphylatoxin;    Chemokine;    AD;    Alzheimer's disease;    C;    complement;    CNS;    central nervous system;    C3aR;    C3a receptor;    C5aR;    C5a receptor;    IL;    interleukin;    IP-10;    interferon-γ-inducible protein of 10 kDa;    Ltn;    lymphotactin;    MAP;    multiple-associated-peptide;    MCP;    monocyte chemoattractant protein;    MIP;    macrophage inflammatory protein;    MS;    multiple sclerosis;    PTX;    pertussis toxin;    RPA;    ribonuclease protection assay;    RANTES;    regulated on activation;    normal T cells expressed and secreted;    TNF-α;    tumor necrosis factor α;   

DOI  :  10.1016/S0014-5793(03)00060-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The complement (C) system, a major component of the innate immune system, has been described as a factor implicated in some brain disorders. C activation leads to the release of anaphylatoxins, two proinflammatory polypeptides acting through specific receptors that have been detected on brain cells. Here, we examined the effect of anaphylatoxins on chemokine expression by human astrocytes. We showed that anaphylatoxins significantly increase chemokine mRNA expression. However, anaphylatoxin-induced chemokine secretion (interleukin-8) was observed only in the presence of interleukin-1β. Thus, anaphylatoxins could initiate a chemokine cascade and, at least in part, be involved in pathogenesis of the brain.

【 授权许可】

Unknown