Statin and fibrate associed myopathy: study of eight patients

Arquivos de Neuro-Psiquiatria

Alzira A. Siqueira Carvalho¹  Ürsula Waleska Poti Lima¹  Raul Alberto Valiente¹ 

[1] ,Hospital Santa Marcelina Serviço de Neurologia Clínica São Paulo SP ,Brasil

关键词: statins;    fibrates;    myopathy;    muscle biopsy;    creatine kinase;    estatinas;    fibratos;    miopatia;    biopsia muscular;    creatinoquinase;   

DOI  :  10.1590/S0004-282X2004000200013

来源: SciELO

【 摘 要 】

Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms.

【 授权许可】

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