European Journal of Medical Research | |
Myositis associated with localized lipodystrophy: an unrecognized condition? | |
A Riecker2  A-D Sperfeld2  S Klein1  A Ernst1  P Weydt2  H-J Gdynia2  | |
[1] Department of Radiology, University of Ulm, Germany;Department of Neurology, University of Ulm, Germany | |
关键词: muscle biopsy; myopathy; myositis; lipoatrophy; Lipodystrophy; | |
Others : 1093769 DOI : 10.1186/2047-783X-14-5-228 |
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received in 2008-05-20, accepted in 2008-07-24, 发布年份 2009 | |
【 摘 要 】
Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association with localized lipodystrophy. Immunohistochemical stainings revealed a regular pattern of dystrophin, dysferlin, sarcoglycans, and theletonin. Furtermore, there was no evidence of Lamin A/C deficiency. A nearly identical clinical and histological picture has been described in three patients up to now. Although it is difficult to speculate on a causative pathophysiological mechanism at this time, it is possible that this association represents an unrecognized condition.
【 授权许可】
2009 I. Holzapfel Publishers
【 预 览 】
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Figure 1. | 60KB | Image | download |
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