Myositis associated with localized lipodystrophy: an unrecognized condition?

European Journal of Medical Research

A Riecker²  A-D Sperfeld²  S Klein¹  A Ernst¹  P Weydt²  H-J Gdynia² 

[1] Department of Radiology, University of Ulm, Germany;Department of Neurology, University of Ulm, Germany

关键词: muscle biopsy;    myopathy;    myositis;    lipoatrophy;    Lipodystrophy;   

Others  :  1093769
DOI  :  10.1186/2047-783X-14-5-228

 received in 2008-05-20, accepted in 2008-07-24,  发布年份 2009

【 摘 要 】

Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association with localized lipodystrophy. Immunohistochemical stainings revealed a regular pattern of dystrophin, dysferlin, sarcoglycans, and theletonin. Furtermore, there was no evidence of Lamin A/C deficiency. A nearly identical clinical and histological picture has been described in three patients up to now. Although it is difficult to speculate on a causative pathophysiological mechanism at this time, it is possible that this association represents an unrecognized condition.

【 授权许可】

   
2009 I. Holzapfel Publishers

【 图 表 】

Figure 1.

Figure 2.

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