Toxic myopathies: muscle biopsy features

Arquivos de Neuro-Psiquiatria

Rosana Herminia Scola¹  Eduardo Rafael Pereira¹  Paulo José Lorenzoni¹  Lineu César Werneck¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Internal Medicine DepartmentCuritiba PR ,Brasil

关键词: myopathy;    drug;    iatrogenic myopathy;    toxic myopathy;    muscle biopsy;    miopatias;    drogas;    miopatia iatrogênica;    miopatia tóxica;    biópsia muscular;   

DOI  :  10.1590/S0004-282X2007000100018

来源: SciELO

【 摘 要 】

Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.

【 授权许可】

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