The central role of RNA in the genetic programming of complex organisms

Anais da Academia Brasileira de Ciências

John S. Mattick¹ 

[1] ,University of Queensland, Brisbane Institute for Molecular Bioscience ,Australia

关键词: development;    noncoding RNA;    epigenome;    gene regulation;    RNA editing;    brain;    desenvolvimento;    RNA não-codificador;    epi-genoma;    regulação gênica;    edição de RNA;    cérebro;   

DOI  :  10.1590/S0001-37652010000400016

来源: SciELO

【 摘 要 】

Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain.

【 授权许可】

CC BY   
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