An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress

Anais da Academia Brasileira de Ciências

Michele A. Zacks²  Jian-jun Wen¹  Galina Vyatkina¹  Vandanajay Bhatia¹  Nisha Garg¹ 

[1] ,University of Texas Medical Branch Department of Pathology Galveston TX ,USA

关键词: chagasic cardiomyopathy;    reactive oxygen species;    inflammation;    mitochondria;    oxidant;    oxidative damage;    cardiomiopatia chagásica;    espécies reativas do oxigênio;    inflamação;    mitocôndria;    relação oxidante;    danos oxidativos;   

DOI  :  10.1590/S0001-37652005000400009

来源: SciELO

【 摘 要 】

There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role of oxidative stress in chagasic cardiomyopathy (CCM) remains incomplete. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, electron transport chain dysfunction and its role in sustaining oxidative stress in myocardium. We discuss the literature reporting the consequences of sustained oxidative stress in CCM pathogenesis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License