Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy

Jornal Brasileiro de Patologia e Medicina Laboratorial

Joselito Nardy Ribeiro²  André Romero Da Silva²  Renato Atilio Jorge¹ 

[1] ,Universidade Estadual de Campinas Institute of Chemistry Campinas São Paulo ,Brazil

关键词: Photodynamic therapy;    Apoptosis;    Mitochondria;    Terapia fotodinâmica;    Apoptose;    Mitocôndria;   

DOI  :  10.1590/S1676-24442004000600005

来源: SciELO

【 摘 要 】

Photodynamic therapy (PDT), a promising cancer treatment that employs a combination of a photosensitizing chemical, oxygen, and visible light, induces apoptosis in tumor cells. However, the precise mechanism of PDT-induced apoptosis is not well characterized. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT are localized in or have a major influence on mitochondria. The treatment with PDT causes mitochondrial damage and induces apoptosis through the release of cytochrome c (cyt c), apoptosis-inducing factor (AIF), Smac/DIABLO and certain procaspases. Proapoptotic and antiapoptotic members of BcL-2 family regulate the release of these proteins from mitochondria. The purpose of this mini-review is to present some recent publications that focus on the involvement of the mitochondria in apoptosis of cancer cells induced by PDT.

【 授权许可】

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