Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Jornal Brasileiro de Patologia e Medicina Laboratorial

Monique Morgado Loureiro²  José Carlos Morais¹  Cristiane Bedran Milito¹  Rodrigo Doyle Portugal²  Wolmar Pulcheri²  Nelson Spector² 

[1],Universidade Federal do Rio de Janeiro Faculdade de Medicina Hematology Service

关键词: Hodgkin's disease;    Epstein-Barr virus;    LMP1;    Doença de Hodgkin;    Vírus Epstein-Barr;    LMP1;   

DOI  :  10.1590/S1676-24442004000100010

来源: SciELO

【 摘 要 】

Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Hodgkin's disease (HD), and the association between EBV and HD is influenced by the patients' socioeconomic status, age and the presence of mixed cellularity (MC) histological subtype. The prevalence of EBV in HD varies widely. This study was undertaken to determine the prevalence of EBV in HD in a Brazilian population. We studied 64 cases with a monoclonal antibody to the EBV latent membrane protein-1 (LMP1). EBV was detected in 35 of the 64 cases (55%) and its presence was significantly correlated with the MC subtype (OR = 9; IC 95% = 1.66 - 66; p = 0,0015). These results support that EBV is related to HD in a Brazilian population.

【 授权许可】

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