Vanishing bile duct syndrome in Hodgkin's disease: case report

Sao Paulo Medical Journal

Marta Soares Rossini²  Irene Lorand-metze¹  Gislaine Borba Oliveira²  Cármino Antonio De Souza¹ 

[1] ,State University of Campinas Hematology and Blood Transfusion Center Campinas,Brazil

关键词: Hodgkin's disease;    Vanishing bile duct syndrome;    Liver failure;    Doença de Hodgkin;    Síndrome do desaparecimento dos dutos biliares;    Falência hepática;   

DOI  :  10.1590/S1516-31802000000500008

来源: SciELO

【 摘 要 】

CONTEXT: Liver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now. OBJECTIVE: To describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome. DESIGN: Case report. CASE REPORT: A 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.

【 授权许可】

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