Histological classification of 1,025 cases of Hodgkin's lymphoma from the State of São Paulo, Brazil

Sao Paulo Medical Journal

José Vassallo²  Roberto Pinto Paes¹  Fernando Augusto Soares¹  Yara Menezes¹  Vera Aldred¹  Karina De Cássia Braga Ribeiro¹  Antonio Correa Alves¹ 

[1] ,Universidade Estadual de CampinasCampinas São Paulo

关键词: Hodgkin's disease;    Pathology;    Classification;    Lymphoma;    Neoplasms;    Doença de Hodgkin;    Patologia;    Classificação;    Linfoma maligno;    Neoplasias;   

DOI  :  10.1590/S1516-31802005000300009

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: It is currently asserted that, in industrialized countries, nodular sclerosis is the most frequent type of Hodgkin's lymphoma, in contrast to developing countries, where mixed cellularity and lymphocyte depletion are more frequently seen. The objective was to review histological data from cases of Hodgkin's lymphoma from São Paulo and Campinas cities. DESIGN AND SETTING: Cross-sectional histopathological analysis, in four university hospitals and one cancer care center. METHODS: 1,025 cases diagnosed as Hodgkin's lymphoma between 1990 and 2000 were collected from five institutions; 631 of them (61.5%) had been immunophenotyped using antibodies to CD20, CD3, CD15 and CD30. The relative frequencies of histological types (as informed by the contributing authors, who are hematopathologists in their institutions) were determined according to age and gender. RESULTS: The Hodgkin's lymphoma types were distributed as follows: lymphocyte predominance 4.8%, nodular sclerosis 69.2%, mixed cellularity 21.1% and lymphocyte depletion 4.6%. CONCLUSIONS: The controversy regarding the frequencies of Hodgkin's lymphoma types within the Brazilian setting seems to be due to the small number of cases in previous studies. The present data show a picture close to the situation in the industrialized countries.

【 授权许可】

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