Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis

Brazilian Journal of Microbiology

Ana Raquel Mano Meinerz²  Melissa O. Xavier¹  Marlete Brum Cleff²  Isabel Martins Madrid¹  Márcia Oliveira Nobre¹  Mário Carlos Araújo Meireles¹  João Roberto Braga De Mello² 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Veterinária Programa de Pós-Graduação em Ciências VeterináriasPorto Alegre RS ,Brasil

关键词: itraconazole;    terbinafine;    sporotrichosis;    antifungal;    itraconazol;    terbinafina;    esporotricose;    antifúngico;   

DOI  :  10.1590/S1517-83822008000400025

来源: SciELO

【 摘 要 】

Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x10³ S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0,0004), as well as in the positive organ cultures of microorganism from the organ (p=0,0142). With these results it is possible to conclude that the antifungals studied are effective in the treatment of experimental systemic sporotrichosis.

【 授权许可】

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