Aeromonas associated diarrhoeal disease in south Brazil: prevalence, virulence factors and antimicrobial resistance

Brazilian Journal of Microbiology

Ivani M.f. Guerra²  Raquel Fadanelli²  Manuela Figueiró²  Fernando Schreiner¹  Ana Paula L. Delamare²  Claudia Wollheim¹  Sérgio Olavo P. Costa²  Sergio Echeverrigaray² 

[1] ,Universidades de Caxias do Sul Instituto de Biotecnologia Caxias do Sul RS ,Brasil

关键词: Aeromonas;    diarrhea disease;    virulence factors;    antimicrobial resistance;    Aeromonas;    diarréia;    fatores de virulência;    resistência antimicrobiana;   

DOI  :  10.1590/S1517-83822007000400011

来源: SciELO

【 摘 要 】

Aeromonas were isolated from 27 (6.6%) of 408 patients admitted with acute gastroenteritis in two hospitals at Rio Grande do Sul, Brazil. Isolates were classified as A. hydrophila (51.8%), A. caviae (40.8%), and A. veronii biotype sobria (7.4%). The highest prevalence of Aeromonas associated infections occurred in lactants and children. Virulence genes (aerA -aerolysin/hemolysin, ahpA -serine-protease, satA - glycerophospholipid-cholesterol acyltransferase, lipA -lipase, and ahyB -elastase) and virulence factors (hemolytic, proteolitic, lipolitic activities, and biofilm formation) were identified in most A. hydrophila and A. veronii biotype sobria isolates, with lower frequencies on A. caviae. All Aeromonas isolates were resistant to ampicillin, ticarcillin/clavulanic acid, cephalotin, and cephazolin, and most of them (>70%) exhibited resistance to imipenem, carbenicillin, amoxillin/sulbactan, and piperacillin. Multiple-resistance, more than four antibiotics, was evidenced in 29.6% of the isolates. The most efficient antibiotics were the quinolones (ciprofloxacin and norfloxacin), and the aminoglycosides (amikacin and netilmicin).

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