Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats

Brazilian Archives of Biology and Technology

Vanessa Santos De Arruda Barbosa²  Maria De Carvalho Xavier Holanda²  Roseane Pereira Da Silva²  Daniel Pereira De Oliveira¹  Maurício Ferreira Da Silva Júnior¹  Elias Herculano De Oliveira¹  Maria Helena Constantino Spyrides¹  Aldo Cunha Medeiros² 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Ciências da Saúde Natal RN ,Brasil

关键词: Antiparasite;    Radiopharmaceutical;    Technetium-99m;    Benznidazole;    Biodistribution;    Trypanosoma cruzi;   

DOI  :  10.1590/S1516-89132008000700028

来源: SciELO

【 摘 要 】

Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.

【 授权许可】

CC BY-NC   
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