Brazilian Archives of Biology and Technology | |
An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m | |
Tania Santos Giani1  Severo De Paoli1  Giuseppe Antonio Presta1  Adalgisa Ieda Maiworm1  Sebastião David Santos-filho1  José Brandão-neto1  Aldo Da Cunha Medeiros1  Adenilson De Souza Da Fonseca1  Mario Bernardo-filho1  | |
[1] ,Universidade Federal do Rio Grande do Norte Centro de Ciências da Saúde Natal RN ,Brasil | |
关键词: Technetium-99m; Red blood cell; Oxidant agent; Radiobiocomplex; Plasma proteins; Buzhong Yi Qi Wan; | |
DOI : 10.1590/S1516-89132007000600013 | |
来源: SciELO | |
【 摘 要 】
Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99mTc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and 99mTc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated. Buzhong extract at the highest concentrations used altered significantly (p<0.05) the %ATI in blood constituents. Substances present in the Buzhong extract could alter the cellular membrane and/or generation of free radicals that have oxidant properties modifying the labeling of blood constituents with 99mTc.
【 授权许可】
CC BY-NC
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