Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats

Brazilian Journal of Medical and Biological Research

S.r.f. Moreno²  A.l.c. Silva¹  G. Diré¹  H. Honeycut¹  J.j. Carvalho¹  A.l. Nascimento¹  M. Pereira¹  E.k. Rocha¹  M. Oliveira-timóteo²  A. Arnobio²  B. Olej²  M. Bernardo-filho¹  L.q.a. Caldas² 

[1] ,Universidade Federal Fluminense Programa de Pós-Graduação em Ciências Médicas Niterói RJ ,Brasil

关键词: Uncaria tomentosa;    Biodistribution;    Sodium pertechnetate;    Radiobiocomplex;   

DOI  :  10.1590/S0100-879X2007000100010

来源: SciELO

【 摘 要 】

The aim of the present study was to determine the effect of the oral ingestion of an extract of the herb Uncaria tomentosa (cat's claw) on the biodistribution of the radiobiocomplex sodium pertechnetate (Na99mTcO4) in rats. The animals (male Wistar rats, 2 months old, 180-220 g), were treated (1 mL) with an U. tomentosa extract (32 mg/mL, N = 5) or 0.9% NaCl solution (control, N = 5) for 7 days. After this period, Na99mTcO4 (3.7 MBq, 0.3 mL) was injected through the ocular plexus and after 10 min the rats were killed, the organs isolated and counted in a well-gamma counter. A significant (P < 0.05) alteration in Na99mTcO4 uptake i) from 0.57 ± 0.008 to 0.39 ± 0.06 %ATI/organ (P < 0.05) and from 0.57 ± 0.17 to 0.39 ± 0.14 %ATI/g (P < 0.05) was observed in the heart, ii) from 0.07 ± 0.02 to 0.19 ± 0.07 %ATI/g in the pancreas, and iii) from 0.07 ± 0.01 to 0.18 ± 0.07 %ATI/g (P < 0.05) in muscle after treatment with this extract. Although these results were obtained with animals, caution is advisable in the interpretation of the nuclear medicine examination when the patient is using this herb. This finding is probably an example of drug interaction with a radiopharmaceutical, a fact that could lead to misdiagnosis of the examination in clinical practice with unexpected consequences for the patient.

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