Glucose metabolism in rats submitted to skeletal muscle denervation

Brazilian Archives of Biology and Technology

Wilton Marlindo Santana Nunes¹  Maria Alice Rostom De Mello¹ 

[1] ,Universidade Estadual Paulista Instituto de Biociências Departamento de Educação FísicaRio Claro SP ,Brasil

关键词: Denervation;    Glucose metabolism;    Skeletal muscle;   

DOI  :  10.1590/S1516-89132005000500006

来源: SciELO

【 摘 要 】

This study analyzed the local and systemic effects of immobilization by denervation of the skeletal muscle on glucose metabolism. The rats were submitted to section of the right paw sciatic nerve. A reduction was observed in glucose uptake by the isolated soleus muscle of the denervated paw after 3 and 7 days, but not after 28 days in relation to the control animals. There was no difference after 3 and 7 days in glucose uptake by the soleus muscle of the opposite intact paw in relation to the control. There was increased glucose uptake in the same paw 28 days after denervation. The rate of glucose removal in response to exogenous insulin after 28 days of denervation was significantly higher than in control animals and those observed after 3 and 7 days of denervation. These results suggest that immobilization by denervation interfered not only in glucose metabolism in the skeletal muscle involved but also in other tissues.

【 授权许可】

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