Expression of specific white adipose tissue genes in denervation‐induced skeletal muscle fatty degeneration

FEBS Letters

Reyne, Yves¹  Bacou, Francis¹  Vigneron, Pierre¹  Casteilla, Louis³  Dulor, Jean-Paul²  Nouguès, Jean¹  Cambon, Brigitte¹ 

[1] Laboratoire de Différenciation cellulaire et Croissance, INRA, 2 Place Viala, 34060 Montpellier Cedex 1, France;UFR Productions animales, ENSA M, 2 Place Viala, 34060 Montpellier Cedex 1, France;UPRESA-CNRS 5018, Université Rangueil, 31403 Toulouse Cedex 4, France

关键词: Muscle degeneration;    Denervation;    Skeletal muscle;    White adipose tissue;    ob gene;    Rabbit;    WAT;    white adipose tissue;    BAT;    brown adipose tissue;    A2COL6;    α2 chain of type VI collagen;    LPL;    lipoprotein lipase;    G3PDH;    glycerol 3-phosphate dehydrogenase;    SMa;    fast-twitch semimembranosus accessorius muscle;    SMp;    slow-twitch semimembranosus proprius muscle;    SMm;    semimembranosus muscle;    i.e. fast-twitch semimembranosus accessorius plus slow-twitch semimembranosus proprius muscles;   

DOI  :  10.1016/S0014-5793(98)01216-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue-specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA.

【 授权许可】

Unknown