Efeito do etanol e do peróxido de hidrogênio intragástrico sobre a mucosa gástrica de rã (Rana catesbeiana, SHAW)

Brazilian Archives of Biology and Technology

Hidê Virgínia Estivallet¹  Maria Inês Rodrigues¹  Norma Possa Marroni¹ 

[1] ,Universidade Federal do Rio Grande do Sul Porto Alegre Instituto de Ciências Básicas da Saúde Departamento de FisiologiaPorto Alegre RS ,Brazil

关键词: Gastric acid secretion;    mucus;    ethanol;    hydrogen peroxide;    frog;   

DOI  :  10.1590/S1516-89131998000100007

来源: SciELO

【 摘 要 】

This work investigated the frog gastric mucosa response to hydrogen peroxide and ethanol induced injury. Acid and mucus secretion were estimated "in vitro" in control animals with intragastric absolute ethanol (1ml/30min. or 2ml/60min.) and hydrogen peroxide. The gastric mucosa morphological conditions were assessed "in vivo", concerning lesion area, pH and mucus. Ethanol (1ml/30min.) was observed to cause hyperemia, cell damage, rupture, edema, erosions, necrosis in gastric mucosa and significant increase in acid secretion. Absolute ethanol (2ml/60min.) caused a decrease in acid secretion due to alcalinization and an increase of mucus and pH. Intragastric hydrogem peroxide provoked gastric unwrinkling and hyperemia, acid secretions were not increased, mucus fragmented and the pH was decreased. The results indicate an increase of mucus and acid in response to ethanol and unwrinkling and hyperemia to hydrogen peroxide.

【 授权许可】

CC BY-NC   
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