Antisecretory and Antiulcer Effects of Ebselen, a Seleno-Organic Compound, in Rats

The Japanese Journal of Pharmacology

Yoshiaki Tabuchi¹  Yoichi Kurebayashi¹ 

[1] Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.

关键词: Ebselen;    Gastric ulcer;    Gastric acid secretion;   

DOI  :  10.1254/jjp.61.255

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(11)The effects of ebselen (2-phenyl-1, 2-benzisoselenazol-3(2H)-on), a metal-containing organic compound, on gastric secretion and gastric ulceration were examined in rats. Intraduodenal ebselen (30 to 300 mg/kg)significantly and dose-dependently inhibited gastric secretion in pylorus-ligated rats. Both aspirin and water-immersion restraint stress-induced ulcers were significantly prevented by oral administration of ebselen at doses equivalent to the antisecretory doses. These results indicate that the antisecretory effect of ebselen underlies its antiulcer effect in these models.

【 授权许可】

Unknown