Antibody responses to Hepatitis B and measles-mumps-rubella vaccines in children who received chemotherapy for acute lymphoblastic leukemia

Revista Brasileira de Hematologia e Hemoterapia

Simone Santana Viana¹  Gustavo Santos Araujo¹  Gustavo Baptista De Almeida Faro¹  Lana Luíza Da Cruz-silva¹  Carlos André Araújo-melo¹  Rosana Cipolotti¹ 

[1] ,Universidade Federal de SergipeAracaju SE ,Brazil

关键词: Leukemia;    lymphoid;    Antineoplastic combined chemotherapy protocols;    Immunization;    Viral vaccines;    Child;   

DOI  :  10.5581/1516-8484.20120071

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate viral vaccine antibody levels in children with acute lymphoblastic leukemia after chemotherapy and after vaccine booster doses. METHODS: Antibody levels against hepatitis B, rubella, measles and mumps vaccine antigens were evaluated in 33 children after completing chemotherapy (before and after vaccine booster doses) and the results were compared to the data of 33 healthy children matched for gender, age and social class. RESULTS: After chemotherapy, 75.9%, 67.9%, 59.3% and 51.7% of the patients showed low antibody titers that would be unlikely to protect against exposure to measles, rubella, hepatitis B and mumps, respectively. After receiving a vaccine booster dose for these antigens the patients had high antibody levels consistent with potential protection against measles, mumps and hepatitis B, but not against rubella. CONCLUSION: Extra doses of measles-mumps-rubella plus hepatitis B vaccines are recommended in acute lymphoblastic leukemia patients submitted to treatment after hematologic recovery. After this, viral vaccine antibody levels should be verified to define the individual's protective status.

【 授权许可】

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