Revista Brasileira de Hematologia e Hemoterapia | |
Imatinib resistance: a review of alternative inhibitors in chronic myeloid leukemia | |
Roberta Bitencourt2  Ilana Zalcberg1  Iúri Drumond Louro2  | |
[1] ,Universidade Federal do Espírito Santo Master Program in Biotechnology Vitória ES ,Brazil | |
关键词: Leukemia; myelogenous; chronic; BCR-ABL positive; Protein-tyrosine kinases; Drug resistance; neoplasm; Antineoplastic agents; Piperazines; Pyrimidines; | |
DOI : 10.5581/1516-8484.20110124 | |
来源: SciELO | |
【 摘 要 】
The development of point mutations in the BCR-ABL kinase domain is the main reason for imatinib resistance in chronic myeloid leukemia. Different detection methods are used in chronic myeloid leukemia monitoring, such as direct sequencing, denaturing high performance liquid chromatography and allele specific polymerase chain reaction. Mutation analysis has become mandatory during patient workup of chronic myeloid leukemia in order for the physician to choose the most suitable tyrosine kinase inhibitor. This article, a review of possible therapies used to overcome imatinib resistance, investigates the current position by searching the PubMed electronic database using the following keywords: imatinib, dasatinib, nilotinib, aurora kinase, SRC kinase, mutation, treatment, drugs and resistance. New tyrosine kinase inhibitors include BCR-ABL kinase selective inhibitors, dual ABL/SRC kinase inhibitors and aurora kinase inhibitors. Awareness of the spectrum of new drugs against mutations, in particular the T315I mutation, makes it possible to properly select the best therapy for each patient.
【 授权许可】
CC BY-NC-ND
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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RO202005130164251ZK.pdf | 322KB | download |