Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome

Revista Brasileira de Hematologia e Hemoterapia

Daiana Landenberger De Carvalho¹  Cristian Dias Barbosa¹  André Luiz De Carvalho¹  Sandra Trevisan Beck¹ 

[1] ,Universidade Federal de Santa MariaSanta Maria RS ,Brazil

关键词: HLA antigens;    Fusion proteins;    BCR-ABL;    Genetic predisposition to disease;    Philadelphia chromosome;    Leukemia;    myelogenous;    chronic;    BCR-ABL positive;    Precursor cell lymphoblastic leukemia-lymphoma;   

DOI  :  10.5581/1516-8484.20120072

来源: SciELO

【 摘 要 】

OBJECTIVE: This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. METHODS: Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME). RESULTS: Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3. CONCLUSION: The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.

【 授权许可】

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