Low prevalence of Factor V Leiden and the prothrombin G20210A mutation in a healthy population from the central-south region of Chile

Revista Brasileira de Hematologia e Hemoterapia

Iván Palomo²  Fabian Segovia²  Daniela Parra¹  Marcelo Alarcón²  Edgardo Rojas² 

[1] ,Universidad de Talca Faculty of Health Sciences Department of Clinical Biochemistry and ImmunohematologyTalca,Chile

关键词: Factor V Leiden;    prothrombin G20210A mutation;    Chile;    Fator V Leiden;    mutação da protrombina G20210A;    Chile;   

DOI  :  10.1590/S1516-84842009005000042

来源: SciELO

【 摘 要 】

Thrombosis is a result of the interaction between predisposing genetic polymorphisms and acquired risk factors. The two prothrombotic polymorphisms which are most frequently associated with thrombosis are factor V (FV) Leiden and the prothrombin (PT) G20210A mutation. The objective of this work was to investigate the prevalence of both factors in the central-south region of Chile. Determination of the frequency was carried out by means of a genetic analysis of 1200 healthy, non-native individuals. The mutation of FV Leiden was found in 1.25% of the population and the PT G20210A mutation in 1.33%. None of the individuals were homozygosis or had both polymorphisms. The prevalences of FV Leiden and the PT G20210A mutation are less common in the healthy population.

【 授权许可】

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