Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population

Genetics and Molecular Biology

Magaly B.p.l.v. Lima²  Aldemir Branco De Oliveira-filho²  Júlia F. Campos¹  Fárida C.b.c. Melo¹  Washington Batista Das Neves¹  Raul Antônio Morais Melo¹  José Alexandre Rodrigues Lemos² 

[1] ,Fundação Centro de Hemoterapia e Hematologia do Pará Laboratório de Biologia Celular e Molecular Belém PA ,Brazil

关键词: ABO blood group;    Factor V Leiden;    venous thrombosis;   

DOI  :  10.1590/S1415-47572009000200010

来源: SciELO

【 摘 要 】

Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.

【 授权许可】

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