Frequency of the BCR/ABL rearrangements and associated alterations detected by FISH during monitoring of patients taking imatinib mesylate in isolation

Revista Brasileira de Hematologia e Hemoterapia

Cristina B. Vendrame-goloni²  Andréa B. Carvalho-salles¹  Octávio Ricci Júnior¹  Carlos E. Miguel¹  Agnes C. Fett-conte¹ 

[1],Unesp Ibilce Department of BiologySão José do Rio Preto SP ,Brazil

关键词: Chronic myelogenous leukemia;    imatinib;    FISH;    Leucemia mielóide crônica;    imatinibe;    FISH;   

DOI  :  10.1590/S1516-84842006000200010

来源: SciELO

【 摘 要 】

The introduction of imatinib mesylate as treatment of chronic myelogenous leukemia has saved many patients, but the success of therapy is hampered by resistance and possible non-destruction of the malignant clone. This article describes the cytogenetic responses and abnormal cytogenetic patterns involving the ABL and BCR genes detected by FISH in patients who use exclusively imatinib. The results showed that other alterations involving the BCR and ABL genes do not seem to be related to resistance to the drug as they occur in low frequencies and can not be associated to the cytogenetic response or to the time of treatment. Moreover, the response to imatinib seems to be individual and unpredictable, independent of the time of treatment and of its initiation after diagnosis.

【 授权许可】

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