Peripheral chemokine levels in women with recurrent major depression with suicidal ideation

Revista Brasileira de Psiquiatria

Rodrigo Grassi-oliveira²  Elisa Brieztke¹  Antônio Teixeira¹  Júlio Carlos Pezzi¹  Márcio Zanini¹  Rodrigo Pestana Lopes¹  Moisés Evandro Bauer¹ 

[1] ,Pontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research GroupPorto Alegre,Brazil

关键词: Suicide;    Suicidal Ideation;    Chemokines;    Cytokines;    Major Depressive Disorder;    Mood Disorders;    Inflammation;    Immunity;    Suicídio;    Ideação suicida;    Quimiocinas;    Citocinas;    Transtorno Depressivo Maior;    Transtornos do Humor;    Inflamação;    Imunidade;   

DOI  :  10.1590/S1516-44462012000100013

来源: SciELO

【 摘 要 】

OBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.

【 授权许可】

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