Young people at ultra high risk for psychosis: research from the PACE clinic

Revista Brasileira de Psiquiatria

Alison R. Yung¹  Barnaby Nelson¹ 

[1] ,University of Melbourne Centre for Youth Mental Health

关键词: Diagnosis;    Psychotic disorders;    Schizophrenia;    Biomedical research;    Cognitive therapy;    Diagnóstico;    Transtornos psicóticos;    Esquizofrenia;    Pesquisa biomédica;    Terapia cognitiva;   

DOI  :  10.1590/S1516-44462011000600003

来源: SciELO

【 摘 要 】

Over the last fifteen years, attempts have been made to prospectively identify individuals in the prodromal phase of schizophrenia and other psychotic disorders. The ultra high risk approach, based on a combination of known trait and state risk factors, has been the main strategy used. The validation of the ultra high risk criteria allowed for predictive research in this population in an attempt to identify clinical, neurocognitive and neurobiological risk factors for psychosis onset. It also led to a series of intervention studies in this population, which have included the use of low dose antipsychotic medication, cognitive therapy, and omega-3 fatty acids. Although there is moderate evidence for the effectiveness of specific intervention strategies in this population, the most effective type and duration of intervention is yet to be determined. A current controversy in the field is whether to include an adaption of the ultra high risk criteria (the attenuated psychosis syndrome) in the next version of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).

【 授权许可】

CC BY-NC   
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