Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD)

Revista Brasileira de Psiquiatria

Jaime E. C. Hallak²  João Paulo Machado-de-sousa²  José Alexandre S. Crippa²  Rafael Faria Sanches²  Clarissa Trzesniak²  Cristiano Chaves²  Sandra Aparecida Bernardo²  Simone Cecílio Regalo¹  Antonio Waldo Zuardi² 

[1] ,Universidade de São Paulo Department of Neuroscience and Behavior University Hospital of the Ribeirão Preto Medical SchoolRibeirão Preto SP ,Brazil

关键词: Schizophrenia;    Cognition;    Cannabidiol;    Psychotic disorders;    Esquizofrenia;    Cognição;    Canabidiol;    Transtornos psicóticos;   

DOI  :  10.1590/S1516-44462010000100011

来源: SciELO

【 摘 要 】

OBJECTIVE: The last decade has seen increasing evidence of dysfunctions in the endogenous cannabinoid system in schizophrenia and of its relationship with the typical cognitive impairment of the disorder. Studies in animal models, healthy volunteers, and psychotic patients clearly suggest an antipsychotic-like effect of cannabidiol. This study investigated the effects of cannabidiol on selective attention in 28 schizophrenic patients using the Stroop Color Word Test and on these patients' electrodermal responsiveness to auditive stimuli. METHOD: The subjects attended two experimental sessions, the first one without the administration of drugs. In the second session the subjects were divided into three groups that received either a single dose of cannabidiol 300mg or cannabidiol 600mg or placebo. RESULTS: The three groups did not differ significantly with respect to electrodermal measures in the two experimental sessions. When the first and second sessions were compared improved performance was found in all three groups, with patients who received placebo and cannabidiol 300mg performing better than those who received cannabidiol 600mg. CONCLUSION: The single, acute administration of cannabidiol seems to have no beneficial effects on the performance of schizophrenic patients in the Stroop Color Word Test, although the hypothesis that chronic administration may lead to improvement cannot be disregarded.

【 授权许可】

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