The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

Revista Brasileira de Psiquiatria

Sandra Petresco²  Elisa Kijner Gutt¹  Renata Krelling¹  Francisco Lotufo Neto¹  Luis Augusto Paim Rohde¹  Ricardo Alberto Moreno² 

[1] ,Universidade de São Paulo Department and Institute of Psychiatry Clinical HospitalSão Paulo SP ,Brazil

关键词: Bipolar disorder;    Psychopathology;    Risk factors;    Children;    Adolescent;    Transtorno bipolar;    Psicolopatologia;    Fatores de risco;    Crianças;    Adolescentes;   

DOI  :  10.1590/S1516-44462009000300009

来源: SciELO

【 摘 要 】

OBJECTIVE: No previous study has assessed the occurrence of psychopathology in offspring of bipolar women from South America. The objective of this study was to assess the prevalence of psychopathology in offspring of bipolar mothers from Brazil compared with two control groups. METHOD: Children and adolescents aged 6 to 18 years of bipolar disorders mothers (n = 43), mothers with other mild to moderate mental disorders (n = 53) and mothers without any psychiatric disorder (n = 53) were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia present and lifetime version, the Child Behavior Checklist and the Youth Self-Report. Raters were blind to the mothers' diagnoses, who were interviewed by means of the Structured Clinical Interview. RESULTS: Bipolar offspring had twice the chance of having one or more lifetime Axis I diagnoses [prevalence ratio = 2.11 (95% CI: 1.30-3.42) and p = 0.003] and 2.8 higher risk of having a lifetime anxiety disorder [prevalence ratio = 2.83 (95% CI: 1.39-5.78) e p = 0.004] than the offspring of mothers with no mental disorder. In addition, significantly higher scores on Child Behavior Checklist thought problems and Youth Self-Report social problems, as well as anxiety/depression and internalizing problems were observed. CONCLUSION: Our results confirm previous findings suggesting higher psychiatric problems in offspring of bipolar mothers and extend them to the Brazilian society

【 授权许可】

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