Serum levels of brain-derived neurotrophic factor in acute and posttraumatic stress disorder: a case report study

Revista Brasileira de Psiquiatria

Simone Hauck²  Fabiano Gomes¹  Érico De Moura Silveira Júnior²  Ellen Almeida²  Marianne Possa²  Lúcia Helena Freitas Ceitlin² 

[1] ,Hospital de Clínicas de Porto Alegre Center for Study and Treatment of Traumatic Stress Porto Alegre RS ,Brazil

关键词: Stress disorders;    posttraumatic;    Stress disorders;    traumatic;    acute;    Brain-derived neurotrophic factor;    Treatment outcome;    Case studies;    Transtornos de estresse pós-traumático;    Transtornos de estresse traumático agudo;    Fator neurotrófico derivado do encéfalo;    Resultado de tratamento;    Estudo de casos;   

DOI  :  10.1590/S1516-44462009000100012

来源: SciELO

【 摘 要 】

OBJECTIVE: The aim of this study was to evaluate brain-derived neurotrophic factor levels in two patients, one with posttraumatic stress disorder and one with acute stress disorder, before and after treatment, and to compare those levels to those of healthy controls. METHOD: Brain-derived neurotrophic factor level, Davidson Trauma Scale, Beck Depression Inventory, Global Assessment of Functioning, and Clinical Global Impression were assessed before and after 6 weeks of treatment. RESULTS: Brain-derived neurotrophic factor levels were higher in patients than in matched controls before treatment. After 6 weeks, there was a reduction in symptoms and an improvement in functioning in both cases. At the same time, brain-derived neurotrophic factor levels decreased after treatment, even in case 2, treated with psychotherapy only. CONCLUSIONS: These results suggest that serum levels of brain-derived neurotrophic factor, as opposed to what has been described in mood disorders, are increased in posttraumatic stress disorder as well as in acute stress disorder.

【 授权许可】

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