Subclinical hypothyroidism: psychiatric disorders and symptoms

Revista Brasileira de Psiquiatria

Cloyra Almeida²  Marco Antônio Brasil¹  Antônio José Leal Costa¹  Fabiola A A Reis¹  Vaneska Reuters¹  Patrícia Teixeira¹  Márcia Ferreira¹  Amanda M Marques¹  Bianca A Melo¹  Letícia B B De M Teixeira¹  Alexandre Buescu¹  Mário Vaisman¹ 

[1] ,Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Graduate Program in EndocrinologyRio de Janeiro RJ ,Brazil

关键词: Hypothyroidism;    Anxiety disorders;    Mood disorders;    Symptoms;    Prevalence;    Hipotireoidismo;    Transtornos da ansiedade;    Transtornos do humor;    Sintomas;    Prevalência;   

DOI  :  10.1590/S1516-44462007000200013

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. METHOD: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 µU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory. RESULTS: Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001). CONCLUSION: Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License