Revista Brasileira de Psiquiatria | |
Subclinical hypothyroidism: psychiatric disorders and symptoms | |
Cloyra Almeida2  Marco Antônio Brasil1  Antônio José Leal Costa1  Fabiola A A Reis1  Vaneska Reuters1  Patrícia Teixeira1  Márcia Ferreira1  Amanda M Marques1  Bianca A Melo1  Letícia B B De M Teixeira1  Alexandre Buescu1  Mário Vaisman1  | |
[1] ,Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Graduate Program in EndocrinologyRio de Janeiro RJ ,Brazil | |
关键词: Hypothyroidism; Anxiety disorders; Mood disorders; Symptoms; Prevalence; Hipotireoidismo; Transtornos da ansiedade; Transtornos do humor; Sintomas; Prevalência; | |
DOI : 10.1590/S1516-44462007000200013 | |
来源: SciELO | |
【 摘 要 】
OBJECTIVE: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. METHOD: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 µU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory. RESULTS: Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001). CONCLUSION: Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.
【 授权许可】
CC BY-NC
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