Usefulness of serotoninergic challenge with oral citalopram

Revista Brasileira de Psiquiatria

Paulo Mattos²  Vanessa A Franco²  François Noel¹  Daniel Segenreich²  José Carlos Gonçalves¹ 

[1],Universidade Federal do Rio de Janeiro Psychiatry Institute Rio de Janeiro RJ ,Brazil

关键词: Citalopram;    Cortisol;    Prolactin;    GH;    Challenge;    Citalopram;    Cortisol;    Prolactina;    GH;    Desafio;   

DOI  :  10.1590/S1516-44462006000300011

来源: SciELO

【 摘 要 】

OBJECTIVE: Challenge tests designed to evaluate serotoninergic pathways have widely used intravenous citalopram. Oral citalopram has also been used, but unsatisfactory results were obtained with a dose of 20 mg. The objective of this study was to determine whether a higher oral dose would reproduce similar to those described for intravenous administration. To that end, we evaluated cortisol, growth hormone and prolactin levels. METHOD: Eight healthy male volunteers were evaluated in a randomized crossover challenge test with 40 mg of oral citalopram or placebo. RESULTS: Cortisol levels increased at 2-4h after the oral citalopram intake, with a small amplitude peak occurring in two-thirds of the subjects. Levels of prolactin and growth hormone remained unchanged throughout the study. CONCLUSION: The use of oral citalopram might present an alternative in serotoninergic challenge tests, but higher doses are required.

【 授权许可】

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