Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis

Revista Brasileira de Psiquiatria

Andrea De Abreu Feijó De Mello¹  Marcelo Feijó De Mello¹  Linda L Carpenter¹  Lawrence H Price¹ 

[1] ,Brown Medical School Department of Psychiatry and Human Behavior Butler Hospital Rhode Island ,USA

关键词: Stress;    Depression;    Hypothalamus;    Pituitary-adrenal system;    Corticotropin releasing hormone (CRH);    HPA axis;    Child abuse;    Childhood trauma;    Estresse;    Depressão;    Hipotálamo;    Sistema pituitário-adrenal;    Hormônio liberador de corticotropina (HLC);    Eixo HHA;    Abuso contra crianças;    Trauma infantil;   

DOI  :  10.1590/S1516-44462003000400010

来源: SciELO

【 摘 要 】

Over the past 50 years, relationships between stress and the neurobiological changes seen in psychiatric disorders have been well-documented. A major focus of investigations in this area has been the role of the hypothalamic-pituitary-adrenal (HPA) axis, both as a marker of stress response and as a mediator of additional downstream pathophysiologic changes. This review examines the emerging literature concerning the relationship between stress, HPA axis function, and depression, as well as the role of early life stress as an important risk factor for HPA axis dysregulation. The more recent studies reviewed suggest that the prominence of HPA axis hyperactivity in adults with depressive and anxiety disorders may constitute a link between the occurrence of adversity in childhood and the development of adult psychopathology

【 授权许可】

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